Matridur ® and Matridex ®

Matridur & Matridex Logo

Product Summary

Launched in the United Kingdom in 2004.

What do they contain?

Matridur is a mixture of non-animal stabilised hyaluronic acid 25mg/ml and cross-linked hyaluronic acid 25mg/ml.

Matridex contains cross linked hyaluronic acid and dextranomers (dextran molecules). These form microparticles with a positively charged surface and a diameter of approx 80-120 microns. Such microparticles have been used in surgical applications where healing needs to be as fast as possible and where regeneration and bulking of soft tissue is required, for example in the treatment of incontinence (to regenerate, bulk and repair the delicate urethra).

Is a skin test required before treatment?


Is it temporary or permanent?

With Matridur, the hyaluronic acid is completely broken down within the skin over a period of months, eventually leaving no trace of the filler.

With Matridex, the hyaluronic acid is broken down, and the microspheres breakdown into sugars within 2 years.

Licenced status

Medical device.

Should be used by

Trained members of the medical profession only.

Product range


For finer lines such as laughter lines around the eyes and the smoker lines or peri-oral lines above the top lip.


Matridex is used for regeneration of the soft tissue of the face when altered by damage, disease or ageing.

It can be used for the nose to mouth lines and to remodel the face; fill cheeks, hollows and restore contour.

Not to be used in

Individuals with a known hypersensitivity to hyaluronic acid.

Pregnant or breastfeeding women.

Individuals with a history of autoimmune disease.

Patients who have a tendency to develop hypertrophic scars.

Duration of effect

With Matridur, the duration of effect depends upon the degree of correction required, your age and lifestyle as well as the correct placement of the product by a practitioner, but on average effects last for 6 - 9 months.

Matridex results will last 12 - 24 months depending upon the area treated.

Reported side effects

Transient erythema (redness), swelling, pain, itching, discolouration or tenderness at the implant site. Typically resolution is spontaneous, within one or two days after injection into the skin, and within a week after injection into the lips. Additionally, temporary palpable lumpiness has been noted after injection in some patients.

Localised reactions thought to be of a hypersensitivity nature have been reported in about 1 in every 2000 treated patients. Redness, tenderness and rarely acneform papules may occur.

In rare cases granuloma formation (which show up as red lumps underneath the skin and may be permanent) can occur.


Again, this depends on area treated and how much is required, and the practitioner doing the treatment, but ranges are in the region of £200 - £300 per syringe.