Stylage®

Product Summary

Introduced to the UK in approximately 2011 and manufactured by the French company Vivacy Laboratories, Stylage® is the first hyaluronic acid dermal filler with local anaesthetic lidocaine (lignocaine) and an antioxidant, in the form of mannitol, all within one product.

With the various different concentrations Stylage can target and treat according to the degree of the sunken dermis or area of skin. Stylage corrects wrinkles (forehead, crows feet, nose and chin wrinkles, mouth wrinkles, etc.), gives the skin lost moisture and enables modelling of facial shapes and contours (cheekbones, hollow cheeks, lip volume and oval face).

 

Generic name

Non-animal hyaluronic acid gel with lignocaine (lidocaine) and mannitol.

 

What does it contain?

Stylage S, M, L, XL and Special Lips - Cross-linked hyaluronic acid IPN-Like + Mannitol; specifically designed for the natural correction of superficial lines and wrinkles.

Stylage M and Special Lips Lidocaine - Cross-linked hyaluronic acid IPN-Like + Mannitol + 0.3% of lidocaine.

Stylage products are combined with an antioxidant, Mannitol, naturally present in nature in celery, olives and raspberries to reduce the side effects of hyaluronic acid (redness and swelling). The presence of Mannitol, the "free radical scavenger", limits the effects of free radicals on the dermis and on the product injected, thus reducing the risk of post-injection inflammation and preventing the hyauronic acid gels structure degradation by the body.

 

How is it made?

With their patented IPN-like® Technology (Interpenetrated Network), Vivacy has created something which has two structures—the monophasic A and B structure, and the IPN-like structure. The two are mechanically independent, so Stylage is easy to inject and the increased density of its cross-linking nodes make it long-lasting. This methods requires less BDDE (a common compound used in cross linking hyauronic acids) which the company claims is more effective and results in a safer, longer lasting product.

 

Is a skin test required before treatment?

No allergy test needed.

 

Is it temporary or permanent?

Temporary due to breakdown of hyaluronic acid in the body.

 

Licenced status

Medical device.

 

Should be used by

Trained members of the medical profession only.

 

Product range

There are 7 different formulations of Stylage available.

 Stylage Hydro

(14mg/g of non-cross linked hyaluronic acid, 1×1ml syringe)

Injected into the superficial dermis using mesotherapy techniques for rehydration of the dermis, skin elasticity improvement, revitalisation of the face, neck and décolleté area and hand rejuvenation.

A treatment programme is recommended to include 3 sessions within 3 weeks to 1 month, with maintenance treatments carried out at intervals of 3 to 6 months to prolong and enhance the effect of the treatment. 

  

 Stylage Hydromax

(12.5mg/g of hyaluronic acid, 1×1ml syringe)

Injected into the superficial dermis using mesotherapy techniques for the treatment of very dry/dehydrated skin; deep, instant hydration or a dermal restructuring treatment, skin elasticity improvement, revitalisation of the face, neck and décolleté area and hand rejuvenation. Stylage HydroMAX is a mesotherapy product, so treats the signs of ageing and skin hydration and not wrinkles.

A treatment programme is recommended to include 2 sessions, depending on the degree of dehydration, carried out at a 1 month interval, followed by 1 further session two months later, if necessary. Regular top-up sessions are also recommended to maintain the effect.

  

 Stylage S

(16mg/g of hyaluronic acid, 2×0.8ml syringes)

Injected into the superficial to mid dermis for superficial and average wrinkles, periorbital wrinkles (crow’s feet), glabellar frown lines (between the eyebrows), fine cheek wrinkles, perioral wrinkles (around the mouth), oral commissures (marionette lines) and dark circles (eye hollows) in the tear trough area under the eye.

  

 Stylage M

(20mg/g of hyaluronic acid, 2×1ml syringes)

Injected into the mid to deep dermis for moderate to severe naso-labial folds, smoothing of wrinkled areas and sagging folds (cheeks, facial oval, chin), oral commissures (marionette lines), cheek wrinkles, hollow temple area, the nose for nasal hump reduction or nasal tip lift and for earlobe reshaping.

Stylage M is also available with Lidocaine to reduce pain for the patient.

  

 Stylage L

(24mg/g of hyauronic acid, 2×1ml syringes)

Injected into the deep dermis for deep to very deep wrinkles, severe naso-labial folds, oral commissures (marionette lines), hand rejuvenation including volume loss treatment on the back of the hands.

  

 Stylage XL 

(26mg/g if hyaluronic acid, 2×1ml syringes)

Injected into the deep dermis or subcutaneous layer for the treatment of facial volume defects, the restoration of facial contours, cheekbone area augmentation and the treatment of slight facial ptosis (skin sagging). 

  

 Stylage Special Lips

(18.5mg/g of hyaluronic acid, 1×1ml syringe)

Injected into the superficial to mid dermis for lip volume augmentation, lip contour definition and correction, correction of a disproportionate upper or lower lip size, reducing perioral lines or smoker’s lines above the upper lip and restoring lip hydration (treatment for red dry lips) 

Stylage Special Lips is also available with Lidocaine to reduce pain for the patient.

  

 

Not to be used in

Individuals with a known hypersensitivity to hyaluronic acid or lidocaine.

Patients with severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies 

 

Duration of effect

According to the manufacturer the various Stylage products will last approximately:

Stylage S - between 9 and 12 Months

Stylage M (Lidocaine) and L – up to 12 months

Stylage XL – 12 months plus 

Stylage Special Lips (Lidocaine) – between 6 and 9 months 

The duration of the effect of all Stylage treatments is very individual and depends on many factors, such as your skin type and structure, age, lifestyle, the area treated and the injection technique used by the practitioner.

 

Reported side effects

Transient erythema (redness), swelling, pain, itching, discolouration or tenderness at the implant site.

 

Costs

The prices charged for Stylage will depend on the specific product used, the amount of syringes used from a pack and the clinic or practitioner. However you can expect to pay from £200 upwards per syringe of Stylage.

 

Clinical Results / Before and Afters

Various before (left) and after (right) photographs showing the improvements achieved with Stylage products.

 

   

 

   
   

 

   

 Lips before (left) and after (right) treatment with Stylage

(Before and after photographs are real patients, your results may differ).

Photos provided courtesy of Vivacy Laboratories 

 

Clinical Trials

  • Pignatti, M., Pedone, A., Baccarani, A., Guaraldi, G., Orlando, G., Lombardi, M., De Santis, G. (2011). High-density Hyaluronic Acid for the Treatment of HIV-related Facial Lipoatrophy. Aesth Plast Surg. URL: https://pubmed.ncbi.nlm.nih.gov/21717261/

    

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