Treatment Options AndPlacement Zones

The mid-face includes:

• The upper cheek
• The area beneath the eyes (indirectly supported)
• The cheekbone contour
• The deep fat pads that shape your facial structure

This is the region Stimulate was designed for, and it is where it performs best.

Why the mid-face is so important

Ageing in the mid-face affects everything:

• Cheeks look flatter
• The under-eye area looks more tired
• Smile lines deepen
• The lower face becomes heavier
• The face loses its natural “lift”

Stimulate restores support, height, and shape right where the ageing process begins.

Stimulate is injected either:

• Subdermally (just beneath the skin)
  
• Over the periosteum (the layer covering the bone)
  

This deep placement matters because:

• It creates a natural lift
• It avoids puffiness on the surface.
• It supports the facial structure from within.
• It enhances the cheekbone contour gently.

Your practitioner will determine the depth based on your anatomy and goals, but Stimulate is consistently recommended for deep structural rejuvenation, according to the product specifications.

A. Deep Medial Cheek (apple of the cheek)

This area provides the “lifted” effect many people seek.

Injecting Stimulate here can:

• Lift the mid-face indirectly
• Support the under-eye hollow
• Reduce early jowl formation
• Create a refreshed appearance

B. Zygomatic Arch (cheekbone contour)

This helps shape the cheekbones without making them appear sharp or artificial.

Benefits:

• Gentle contour
• Better facial symmetry
• A youthful, natural slope to the cheek
• More definition without harsh angles
  
  

C. Lateral Cheek (side of the cheek)

Essential for overall face shape and balance.

Improves:

• Width and support
• Lateral lifting
• The transition between cheek and temple
  
  

D. Pre-periosteal placement for structure

Placing the filler directly on bone allows:

• Maximum lift with minimal volume
• Natural blending with your bone structure
• Long-lasting shape retention

Many fillers used in the cheek area rely purely on volume replacement.

Stimulate, however, offers:

A. Structural Lift

Its high cohesivity allows it to hold shape in deeper layers.

B. Hydration

The HA component binds water to the tissue.

C. Collagen Stimulation

CaHA particles encourage new collagen production over time.

D. Stability Under Pressure and Heat

Stimulate is more resistant to heat-based treatments (IR, RF, HIFU) than BDDE fillers, which can soften or deform under similar conditions.

This combination makes Stimulate especially effective for:

• Natural-looking rejuvenation
• Subtle shaping
• Long-term improvement in tissue quality

Although both versions share identical ingredients — including 26 mg/ml HA and 1 per cent CaHA — the treatment strategy differs for men and women.

For women

Practitioners tend to focus on:

• Soft lift
• Improved roundness
• Gentle cheek contour
• Feminine facial harmony

For men

They may enhance:

• Stronger cheekbone angles
• Higher lateral projection
• Sharper, more structured contours

The product remains the same, but the technique adapts based on anatomy and aesthetic goals.

Stimulate treatments may use either:

Cannula (usually 22G)

Included in the box with the product

Benefits:

• Lower bruising risk
• Gentle, smooth placement
• Ideal for sweeping, broader structural support

Needle (21G)

Also included with the product

Benefits:

• More precise placement
• Excellent for periosteal (bone-level) injection
• Commonly used on the cheekbone

Most practitioners use a combination for optimal results.

Although every face is unique, typical amounts are:

• 1–2 ml for subtle mid-face lift
• 2–3 ml for moderate correction
• 3+ ml for more pronounced structural support
  

Your injector will assess:

• Skin thickness
• Fat pad position
• Level of volume loss
• Desired outcome

Stimulate’s cohesive structure means less product can achieve more lift compared with softer gels.

While Stimulate is built for the mid-face, its lifting effect can improve several related areas:

• Under-eye tiredness (by supporting the mid-cheek)
• Nasolabial folds (smile lines soften when the cheek is lifted)
• Marionette area (jowls appear less pronounced)
• Jawline definition (indirectly enhanced through mid-face support)

This is why mid-face rejuvenation is often the foundation of a full-face approach.

A good practitioner knows that:

• Deep placement = structural lift
• Correct angle = natural cheek contour
• Balanced distribution = symmetry
• Precise placement = beautiful results

Stimulate performs best when placed:

• Deeply
• Structurally
• In anatomically strategic layers

This is why choosing a skilled injector matters so much - someone experienced with PEG-HA technology and mid-face anatomy.

Stimulate is frequently used in more complex rejuvenation plans because it is stable under heat and integrates well into multi-step approaches like:

• Zaffiro waterpeeling + IR lifting + Stimulate (Nlift protocol)
• Radiofrequency tightening + HA boosters + Stimulate (Nboost protocol)

This is a major advantage when you want comprehensive anti-ageing results.

Stimulate is most effective when used in:

• Deep cheek structures
• Cheekbones
• Mid-cheek support areas
• Bone-level injection planes
• Lateral and medial cheek zones

It lifts, supports, hydrates, and regenerates — all in one treatment.