The StimulateThe Treatment Process

A thorough consultation is the foundation of a safe and successful treatment. Expect your practitioner to spend time listening to your concerns and studying your facial structure in detail.

What your practitioner will assess

They may examine:

• Your natural cheek shape
• The degree of volume loss
• The position of your mid-face fat pads
• Skin thickness
• How your face moves when you smile or talk
• Your bone structure
• Any asymmetry between the two sides

Because Stimulate is placed deep, your injector needs to understand the underlying anatomy more carefully than with superficial fillers.

Medical history matters

You will be asked about:

• Autoimmune conditions
• Thyroid disorders (including Hashimoto’s)
• Prior fillers and treatments
• Medications
• Allergies
• Past complications
• Pregnancy or breastfeeding

Stimulate has demonstrated strong safety even in autoimmune thyroid patients, showing reduced inflammatory infiltration and stable antibody levels after injection (CD4, CD8, CD20 markers decreased) .

However, your injector must still determine if the treatment is appropriate for you.

Agreeing on your goals

Your practitioner will help you define what you’re looking for:

• Natural lift?
• Subtle mid-face support?
• Tear trough softening through cheek support?
• More defined cheeks (especially for men)?
• Prevention rather than correction?

Stimulate is very versatile, so your practitioner will tailor the plan accordingly.

Stimulate treatments require minimal preparation, but your practitioner may advise:

• Avoid alcohol for 24 hours before
• Avoid high-dose ibuprofen or aspirin unless prescribed (to reduce bruising risk)
• Keep the skin clean, with no active breakouts
• Arrive well hydrated

Most importantly, attend your appointment with a clear understanding of your expectations and any questions you wish to have answered.

A typical Stimulate session lasts 20–40 minutes depending on your treatment plan.

A. Cleansing and marking the face

Your skin will be cleansed thoroughly, and the practitioner may use:

• Facial mapping lines
• Anatomic landmarks
• Injection points based on your structural needs

For mid-face rejuvenation, markings often include:

• Deep medial cheek
• Zygomatic arch (cheekbone)
• Lateral cheek support zones

B. Optional numbing

Stimulate does not contain lidocaine. Most practitioners offer:

• Topical anaesthetic
• Ice
• Or rely on the natural pressure sensation rather than pain

Most patients describe the feeling as:

“Pressure and fullness, but not sharp pain.”

C. Cannula or needle entry

According to the product specifications:

• A 21G introducer needle
  
• Or a 22G cannula
  

is recommended and included in the box .

Your practitioner may:

• Use a needle for precise bone-level injections
• Use a cannula for smoother, broader placement with fewer entry points

Often, both are used for the most natural result.

D. The injection itself: deep, structural placement

Stimulate is inserted:

• Subdermally or
• Over the periosteum (bone level)
  

This is crucial for achieving:

• Natural lift
• Structural support
• Smooth cheek contour

Because of its cohesive, stable nature, Stimulate remains in place and integrates well with the surrounding tissue.

E. Sculpting and fine-tuning

After depositing the product, your practitioner may:

• Massage lightly
• Shape the gel
• Balance the symmetry
• Add micro-deposits for definition

With Stimulate, subtlety is key—small amounts can produce significant improvement due to its firmness and lift.

Most people describe the experience as:

• Mild pressure
• A sensation of fullness
• Slight warmth from the skin contact
• An awareness of the cannula moving under the skin

There is rarely sharp pain, and most patients tolerate the treatment easily.

You will be able to see improvement straight away. Your cheeks may look:

• More lifted
• More defined
• Better supported
• Fresher

Common, normal side effects include:

• Mild swelling (usually resolves in 48 hours)
• Tenderness at injection sites
• Small bruises
• A feeling of light pressure or tightness

Because the formula contains Glycine and L-Proline, which help manage swelling, most patients experience minimal downtime .

For the first 24 hours

• Avoid intense exercise
• Avoid touching or pressing the treated area
• Avoid hot showers or saunas
• Avoid makeup over injection points until closed

For the first 48 hours

• Avoid alcohol
• Avoid excessive heat (steam rooms, sunbeds)
• Sleep slightly elevated if swelling occurs

For the first 72 hours

• Avoid heat-based facial treatments (e.g., radiofrequency, infrared, laser)
  
  

Good news

After 72 hours, Stimulate is thermally stable, meaning it holds up better under heat than BDDE fillers, which is one of its biggest advantages for combination treatments.

Stimulate is a unique blend of instant + progressive improvements.

Immediate results (Day 0)

• Lift
• Shape
• Contour
• Better mid-face symmetry

Early results (Week 1–3)

• Integration
• Softening
• Natural blending with your facial movement

Regenerative results (Week 6 onwards)

This is when the CaHA begins stimulating collagen formation.

Studies show:

• Increased fibroblast presence
• Early collagen formation (type III)
• Reduced inflammation in treated tissues

Peak improvement (Month 3)

The combination of structure + collagen stimulation gives the most refined result.

Longevity

The filler itself naturally degrades over six months on average - but collagen benefits can last longer as newly formed fibres remain even after the gel has dissolved.

Many patients return at:

• 3 months for assessment
• 6–12 months for maintenance
• Sooner if more volume is needed

Because Stimulate supports collagen, some patients find they need less product over time, not more.

This is one of the areas where Stimulate shines.

Its PEG crosslinking and heat stability make it ideal for combination protocols such as:

Nlift (mid-face protocol)

• Hydro Deluxe
• Zaffiro waterpeeling & infrared
• Stimulate

Nboost (skin quality protocol)

• Sectum radiofrequency
• Non-crosslinked HA boosters

Laser or light therapies

Performed at appropriate intervals.

Combining treatments often results in:

• Better elasticity
• Deeper regeneration
• More lifted, luminous results

A Stimulate treatment is:

• Thorough
• Customised
• Comfortable
• Quickly completed
• Natural in outcome
• Minimal in downtime
• Progressive in benefits
• Supported by strong clinical safety data

It is ideal for people who want a thoughtful, regenerative approach to mid-face rejuvenation.