How How Stimulate Works

According to the scientific studies in the Neauvia portfolio, PEG provides several key advantages:

• High safety profile
  No pathological inflammatory reactions have been observed with Neauvia PEG-HA devices.
  
  
• No cytotoxicity detected
  Laboratory studies confirm that PEG crosslinking does not harm surrounding cells.
  
  
• No residual crosslinker left behind
  Once the filler breaks down, PEG does not remain in tissues, unlike older crosslinkers.
  
  
• Reversible
  Stimulate can be dissolved with hyaluronidase if needed, giving patients peace of mind.
  
  
• Heat stability
  PEG fillers maintain their structure better under heat-based treatments (radiofrequency, infrared, and HIFU), whereas BDDE fillers can deform or degrade more easily.

This means that PEG gives Stimulate a more natural movement, excellent integration with tissue, and strong performance in combination therapy.

Stimulate contains 1 percent calcium hydroxyapatite, a mineral-like substance that activates the skin’s own repair processes. You’ll often hear CaHA described as biostimulatory, which simply means it encourages the body to make more collagen.

What CaHA does inside the skin

Once injected:

• The CaHA particles gently stimulate fibroblast activity
  
• Fibroblasts are the cells responsible for producing collagen.
• Over weeks, new type III collagen fibres begin to form, improving the quality and firmness of the ski.n

This regenerative action is supported by histological (tissue) studies that show a significant increase in newly formed collagen fibres after treatment.

To keep this easy to understand, imagine Stimulate working on three layers of effect:

A. Immediate structural lift (seconds to minutes)

The PEG-HA gel gives the mid-face instant support and volume, restoring shape and height where it has flattened over time.

B. Hydration and suppleness (days to weeks)

The hyaluronic acid component binds water, improving skin hydration and elasticity.

C. Regeneration and collagen renewal (weeks to months)

This is where Stimulate truly stands apart. Thanks to its CaHA content, it:

• Signals fibroblasts to wake up
• Promotes type III collagen formation
• Strengthens the skin’s internal matrix
• Enhances firmness and texture over time

Clinical studies have shown reduced inflammatory infiltration and improved tissue quality in patients with autoimmune diseases, underscoring its gentle yet effective biological interactions.

Stimulate is injected in deep layers (either subdermal or directly onto the bone layer), which matters because:

• Deep placement creates a more natural contour
• It avoids puffiness or overfilling in superficial layers
• It lifts the mid-face indirectly, making the under-eye area look fresher without injecting there directly

Its rheological properties (cohesivity, viscosity, elasticity) make it particularly well suited for these deeper, structural areas.

Stimulate’s PEG structure has been shown to be more heat-resistant than BDDE fillers. Why does that matter?

• Many patients combine fillers with energy-based devices.
• These devices generate heat to stimulate collagen.
• Traditional fillers can lose structure under heat.
• Stimulate holds up better, maintaining integrity under 45–75°C conditions (simulating IR, RF, and HIFU).

This means you can enjoy combination treatments confidently, knowing the filler is designed to stay stable.

One of the strongest pieces of clinical evidence supporting Stimulate’s safety shows:

• Decrease in inflammatory cell presence after injection
• Reduction in CD4, CD8, and CD20 lymphocytes (immune markers)
• No negative impact on thyroid antibody levels in autoimmune thyroid disease patients

This hints at why PEG is considered so gentle and why many practitioners reach for Stimulate when treating people with more reactive or sensitive immune systems.

Stimulate offers a three-dimensional approach to rejuvenation:

• Volume where you need it
• Hydration through high-quality hyaluronic acid
• Regeneration through CaHA and collagen production
  

It is engineered for natural, predictable, and beautifully integrated results, especially in the mid-face, where the structure is everything.