Pegylated Dermal FillerNeauvia Intense

It belongs to the Neauvia Intense Collection, a portfolio of PEG-crosslinked HA fillers formulated to deliver structural support, natural-looking projection, and long-lasting volumisation.

At its core, Intense is a biodegradable HA hydrogel crosslinked with PEG using Neauvia’s patented Smart Crosslinking Technology, which combines hyaluronic acid with polyethene glycol diglycidyl ether (PEGDE) in a unified polymer network. This approach distinguishes Neauvia from traditional fillers and supports high levels of cohesion, stability, and adaptability within facial tissues. This peg is seen as self in the body, so no risk of reactions

Explicitly designed for mid-face volume restoration, Intense provides deep structural support in the subcutis or over the periosteum, making it particularly suited for cheek enhancement, mid-face contouring, and replenishing age-related volume loss. also chin, jawline, templ,e it’s the scaffolding / the foundations

Key Features of Neauvia Intense

• High HA concentration: 28 mg/ml for robust volumising capability
  
  
• PEG crosslinking: Ensures cohesive, stable gel behaviour and high thermodynamic resistance
  
  
• Amino acid enrichment: Contains Glycine and L-Proline, amino acids involved in protein biosynthesis, which enhance rheological balance and swelling resistance after implantation it hydrates, soothes and brightens.
  
  
• High extrusion force: Supports precise placement for areas requiring structural lift
  
  
• Biodegradable: Naturally resorbed over time, with an average degradation timeline of a minimum of 6 months
  
  
• Class III medical device: Certified under EU MDR 2017/745 and intended for use only by trained physicians
  
  

Where Intense Fits Within the Neauvia Range

Neauvia Intense is part of a broader family of fillers, each engineered for different tissue depths, consistencies, and treatment goals:

• Intense is the strongest and is for deep injection
• Intense LV, for mid-face volume with medium-high extrusion force
• Intense Flux, a medium-extrusion filler ideal for versatile facial rejuvenation
• Intense Lips, specifically formulated for the vermilion or perioral area, with softer flexibility.
• Intense Rheology, designed for superficial or dynamic areas requiring lower HA density
• Intense Man, tailored to male facial anatomy, offering strong structural support and high cohesivity
• Hydro Deluxe is an advanced injectable skin booster that combines 18 mg/ml of pure, non-cross-linked hyaluronic acid with 0.01% Calcium Hydroxyapatite (CaHA), Glycine, and L-Proline to deeply hydrate and stimulate collagen production. 

Together, these products create a versatile ecosystem that enables practitioners to tailor treatment to each patient’s anatomical needs, desired outcomes, and tissue characteristics.

Its design allows practitioners to restore volume precisely where structural support is most needed, particularly in the mid-face.

Smart Crosslinking Technology (PEG Crosslinking)

The backbone of Intense's performance is Neauvia’s patented Smart Crosslinking Technology, which creates a unified molecular network by binding hyaluronic acid with polyethylene glycol diglycidyl ether (PEGDE). This PEG-based system differs significantly from the traditional BDDE crosslinking used in most HA fillers.

How PEG Crosslinking Works

• PEG is a highly biocompatible polymer, widely used in pharmaceutical and medical applications due to its stability and safety profile.
• When used as a crosslinker, PEGDE forms a cohesive hydrogel with HA, imparting mechanical properties to the filler that mimic natural tissue movement.
• PEG crosslinking results in:
  • High cohesivity
  • Enhanced thermal resistance
    
  • High viscoelastic balance
    
  • Reversible filling (responsive to hyaluronidase): It’s not resistant to heat, and Neauvia ethos is smart cross-linking technology, so we stimulate all layers combining different fillers and devices for the best outcomes and limited downtimes

These characteristics support controlled placement, resistance to deformation, and longevity within high-mobility facial areas.

Rheological Properties and Gel Performance

Intense’s formulation contributes to its lifting and volumising capabilities:

1. High HA Concentration: 28 mg/ml

A higher concentration of hyaluronic acid increases filler density and provides the structural firmness required for mid-face volumisation.

2. High Cohesivity for Structural Lift

The gel's cohesivity allows it to maintain its shape and remain in place during facial movement. This makes Intense particularly suitable for cheek restoration, mid-face contouring, and periosteal support.

3. High Extrusion Force

With a high extrusion force, Intense is designed for deeper injection planes and for areas needing firm, reliable projection.

4. Enrichment with Glycine and L-Proline

These amino acids, essential for protein biosynthesis, help regulate the filler’s swelling resistance and optimise its viscoelastic behaviour. They support the hydrogel’s stability once implanted, contributing to predictable hydration.

When glycine + L-proline are used together, they:

• Support collagen production
• Improve skin elasticity and firmness
• Help maintain hydration
• Support repair and barrier health

Biodegradation Timeline and Longevity

Intense gradually breaks down over time through natural metabolic processes.

• The average degradation period is a minimum of 6 m, and due to the mix of products, results get better with time, though individual results vary.
• Longevity depends on:
  • Injection technique
  • Anatomical area treated
  • Patient metabolism
  • Degree of crosslinking and gel density

PEG crosslinking contributes to a well-balanced degradation profile that maintains the filler’s shape and support for the duration of its intended lifespan.

Why This Technology Matters

Patients and practitioners often choose Intense over traditional fillers because PEG crosslinking offers:

• A high safety profile, with no detected pathological inflammatory reactions in studies of PEG-HA devices to date
• No cytotoxic activity observed in testing.
• No crosslinker residues remaining after complete degradation
• Heat resistance, enabling combination protocols
  
  

These factors create a reliable, predictable volumising filler suitable for structural facial enhancement.

Its formulation, high cohesivity, and firm gel behaviour make it ideal for patients looking to rejuvenate or enhance the mid-face region with balanced, refined results.

 

Ideal Candidates

1. Adults Experiencing Volume Loss

Intense is intended for individuals who have experienced age-related changes, such as:

• Flattening of the cheeks
• Mid-face hollowing
• Loss of definition due to reduced fat, collagen, or bone support
• It's great on auto immune, no reactions, and doesn’t wear off quickly

Visit Neauvia YouTube channel for more videos.

These are typical concerns among patients aged 30 and above, especially women aged 35–50 who are exploring non-surgical ways to refresh facial contours.

 

2. Patients Seeking Natural-Looking Results

Not everyone wants dramatic augmentation. Intense is suited for people who prefer:

• Subtle lift
• Gentle shaping
• Enhanced facial harmony
• Soft yet supportive projection
  
  

Its cohesive but firm HA structure supports balanced volume without an overfilled appearance.

 

3. Those Needing Deep Structural Support

Intense is injected into the subcutis or over the periosteum, depending on anatomical needs.
 This makes it especially suitable for:

• Cheek enhancement
• Chin and jawline
• Overall facial harmonisation
• Support in areas requiring lift and projection
• Rebuilding facial structure after age-related bone resorption
•  

4. Suitable for Men and Women

While Intense is widely used across genders, Neauvia has also developed Intense Man, a formulation tailored to male facial characteristics, including thicker skin and stronger structural requirements.

 

5. Patients Seeking Facial Harmonisation

Individuals looking to rebalance or harmonise their features without surgical intervention can benefit from Intense. Its cohesive gel network supports symmetrical, proportionate improvements aligned with contemporary aesthetic goals.

 

Who May Not Be Suitable

Intense may not be appropriate for:

• Individuals with active infections or inflammation in the treatment area
• Patients with known allergies to HA-based products (though rare)
• Pregnant or breastfeeding individuals, as a precaution

A trained medical practitioner will conduct a comprehensive assessment to determine suitability and develop a treatment plan.

While Intense serves as the flagship volumising product for mid-face enhancement, the wider collection allows practitioners to customise treatment plans with exceptional precision.

All products in the Intense portfolio share three core attributes:

• PEG-based Smart Crosslinking Technology
  
• Enrichment with Glycine and L-Proline, supporting stability and swelling resistance
• Biodegradability and a high safety profile
  

Below is an overview of each product and its ideal clinical use.

Because Intense and its companion products are Class III medical devices, they must be administered by qualified medical professionals trained in advanced injection techniques.

 

Why Practitioner Expertise Matters

PEG-crosslinked fillers behave differently from traditional BDDE-based fillers. Their cohesivity, density, and structural capabilities require:

• A thorough understanding of facial anatomy
• Precision in injection depth
• Experience with volumising and contouring techniques
• Knowledge of complication management

An experienced aesthetic medical practitioner ensures treatment is not only practical but also safe.

 

What to Look For in a Provider

1. Medical Qualifications

Seek a practitioner who is:

• A licensed doctor, dentist, or aesthetic nurse prescriber
• Experienced in hyaluronic acid facial treatments
• Explicitly trained in Neauvia’s PEG-HA filler techniques
  
  

2. Specialisation in Facial Harmonisation

Clinics that regularly perform:

• Mid-face rejuvenation
• Structural volumising
• Cheek contouring tends to have more profound expertise in using fillers like Intense, which are engineered for lift and projection.
  
  

3. Certification and Product Authenticity

Always ensure your practitioner uses:

• Genuine Neauvia products
• Sealed syringes with traceability labels
• Up-to-date clinical protocols

 

4. Before-and-After Portfolio

A strong visual portfolio helps you understand:

• The practitioner’s style
• Typical results
• Experience with mid-face volumisation
• Whether outcomes align with your aesthetic preferences
  
  

5. Patient Feedback and Reviews

Look for:

• Verified patient testimonials
• Clear explanations of treatment plans
• Transparent communication about expectations and outcomes
  
  

Red Flags to Avoid

• Non-medical injectors
• Extremely low pricing (may indicate poor-quality products or lack of expertise)
• Clinics are unwilling to discuss complications or safety protocols
• Pressure-based sales tactics

The right practitioner will take the time to build a personalised treatment plan, explain risks and benefits, and prioritise your safety and satisfaction.

Although each procedure is tailored to the individual, most treatments follow a clear, structured pathway that ensures safety, accuracy, and natural-looking results.

 

1. Consultation and Facial Assessment

Every treatment begins with a detailed consultation led by a qualified medical aesthetics practitioner. During this appointment, the practitioner will:

• Assess facial structure, symmetry, and areas of volume loss
• Take a medical history to ensure suitability.
• Discuss aesthetic goals and expectations.
• Recommend the most appropriate product within the Neauvia Intense range (Intense, LV, Flux, Lips, Rheology, or Man)
• Explain potential risks and realistic outcomes.

This is also the stage at which a personalised treatment plan is mapped out, often using digital imaging or facial analysis tools to align with the patient's goals.

 

2. Treatment Planning

After the assessment, your practitioner will identify:

• The injection planes required (subcutis, periosteum, intradermal, depending on product choice)
• The type of filler best suited to each is. a
• The volume of product needed (number of syringes)
• The anticipated level of lift, support, or contouring

For example:

• Intense is used for deep structural support over the periosteum.
• Intense Flux and LV may be chosen for softer transitions or mid-layer enhancement.
  
  

3. The Procedure

Preparation

• The area is cleaned and disinfected
• Topical numbing cream may be applied for comfort.
• Injection sites are marked.

The Technique

Depending on the product, injections may be performed using:

• A fine needle
• A cannula
• Or a combination of both

Each product includes specific guidance on suitable tools, such as:

• 21G/22G needles or cannulas for Intense and Intense Man
• 27G needles for Intense Lips and Intense Rheology
• 27G/30G options for Intense Flux

What the Patient Feels

Patients typically experience:

• Mild pressure
• Slight stinging
• A sensation of fullness in the treated area

The procedure usually takes 20–40 minutes, depending on the number of treatment areas.

 

4. Immediate Aftercare

After the injections, your practitioner will give personalised aftercare instructions, which often include:

• Avoiding excessive heat (saunas, steam rooms, hot yoga) for 24–48 hours
• Avoiding intense exercise immediately after treatment
• Refraining from alcohol the same day
• Avoiding pressure on the treated area (sleeping on your back if possible)
• Using a cold compress if slight swelling occurs

These steps help maintain predictable results and minimise unwanted side effects.

 

5. Expected Results and Follow-Up

Most patients notice improvement immediately after treatment, with results refining over the following days.

Your practitioner may schedule a follow-up appointment to:

• Assess the outcome
• Perform minor refinements if necessary.
• Plan a maintenance schedule (typically every 6 months for PEG-crosslinked HA fillers, depending on the area and individual metabolism)

This reflects the advanced PEG crosslinking technology, high-quality formulation, and the expertise required to inject structural volumising products safely and effectively.

Because pricing can vary across clinics, regions, and treatment plans, the figures below should be viewed as guidance rather than fixed numbers.

 

What Influences the Cost?

1. Practitioner Expertise

Highly trained medical practitioners often charge more due to:

• Specialist facial anatomy knowledge
• Experience with PEG-crosslinked HA fillers
• Advanced injection techniques for structural volumisation

Their expertise directly contributes to safer procedures and more refined results.

2. Geographic Location

Prices tend to be higher in:

• Major UK cities
• High-demand aesthetic hubs
• Clinics known for premium or bespoke facial harmonisation services

3. Number of Syringes Required

The overall cost depends on:

• The area being treated
• Depth of volume loss
• Desired level of enhancement

For example, mid-face volumisation often requires 1–2 syringes, though this varies by individual anatomy.

4. Choice of Product Within the Intense Range

Different fillers in the Intense collection may be selected depending on the treatment goals:

• Intense for structural volume
• Intense LV or Flux for softer shaping
• Rheology for superficial refinement
• Lips for perioral enhancement
• Man for masculine definition

Each product carries a different clinical indication and material cost, which influences pricing.

5. Clinic Reputation and Technology

Premium clinics often include:

• Digital facial assessments
• Detailed follow-up appointments
• Advanced safety protocols which can increase overall treatment costs.
  
  

Why You Should Avoid Choosing Based on Price Alone

While it may be tempting to look for the lowest cost available, it is essential to prioritise:

• Practitioner qualifications
  
• Clinic safety standards
  
• Use of genuine Neauvia products
  
• Experience with mid-face or structural filler treatments
  

Cheaper treatments can carry substantial risks, including poor technique, suboptimal results, or unsafe practices.

Understanding what is normal after treatment, what is uncommon, and what requires medical attention helps patients feel confident and well-informed.

 

Common and Expected Side Effects

These reactions are typically mild and settle within a few hours to a few days:

• Swelling around the injection sites
• Redness or slight discolouration
• Tenderness or sensitivity to touch
• Mild bruising
  
• Temporary firmness or feeling of fullness

These effects occur because the skin and underlying tissues respond to the injection and the filler's placement.

 

Less Common Side Effects

Occasionally, patients may experience:

• Small lumps or uneven texture as the filler settles
• Itching
  
• Mild asymmetry while early swelling subsides

These usually resolve on their own or can be adjusted during a follow-up appointment.

 

Rare but Serious Complications

Although complications are rare when qualified medical professionals perform treatment, they can occur. These may include:

1. Vascular Occlusion

A blockage of a blood vessel requires immediate medical intervention.
 Signs include:

• Severe pain
• Skin discolouration
• Cool or pale skin

2. Infection

May present with:

• Warmth
• Increasing redness
• Fever
• Significant swelling

3. Persistent Nodules or Delayed Inflammatory Reactions

Rare with PEG-crosslinked fillers, but possible.

 

Reversibility and Safety

One advantage of Neauvia’s HA fillers is their reversibility. PEG-crosslinked HA remains responsive to hyaluronidase, meaning the filler can be dissolved by a trained professional if required. Studies cited in the product documentation confirm:

• No cytotoxic activity detected in testing
• No crosslinker residues remain after degradation.
  
• High thermodynamic stability that supports safe clinical use

This contributes to Neauvia’s reputation for reliability and patient safety.

 

How to Reduce Risk

Patients can lower risks by choosing a practitioner who is:

• Medically qualified
• Experienced in PEG-HA fillers
• Skilled in facial anatomy
• Equipped to manage complications
• Using authentic Neauvia products

Following personalised aftercare instructions also reduces unnecessary swelling or irritation.