Mastelli & DermaFocus: The Science and Safety Behind Plinest®

Dermafocus
By Dermafocus

At DermaFocus, our mission is to advance regenerative aesthetics through clinically driven innovation, uncompromising safety standards and high-quality education.

Among the many advancements shaping modern aesthetic medicine, polynucleotides stand out for their ability to support the skin’s natural repair processes. At the centre of this innovation is Plinest®, a regenerative treatment created by the Italian pharmaceutical company Mastelli and distributed exclusively in the UK and Ireland by DermaFocus.

Together, Mastelli and DermaFocus form a partnership that brings decades of scientific research, safety, and clinical expertise directly into the hands of qualified medical practitioners.

Here we explore the story behind Plinest® and why this collaboration offers patients an exceptional level of trust and reassurance.

Mastelli: Over 70 Years of Regenerative Expertise

Mastelli’s legacy in polynucleotide science dates back to the 1950s. As pioneers in regenerative medicine, they have developed and refined their polynucleotide formulations over decades of work in:

  • Dermatology
  • Wound healing
  • Ophthalmology
  • Regenerative medicine
  • Tissue repair therapies

This longstanding scientific commitment is the foundation of the Plinest® range, which is now widely used across Europe and beyond.

Mastelli: Over 70 Years of Regenerative Expertise

Mastelli’s involvement in both laboratory research and clinical development ensures Plinest® is not simply a cosmetic product, but a pharmaceutical-grade regenerative therapy backed by real-world evidence.

The Science Behind Plinest®

Plinest® is powered by PN-HPT™ (polynucleotide high purification technology) –Mastelli’s patented process that delivers ultra-pure, biocompatible DNA fragments.

What makes PN-HPT™ unique?

PN-HPT™ removes proteins and impurities, creating polynucleotides that are:

  • Highly purified
  • Extremely well tolerated
  • Suitable for delicate areas (including under the eyes)
  • Consistent and reliable in clinical use

This level of safety and purification is one of the factors that distinguishes Plinest® from generic or unregulated PN products entering the market.

Evidence-Led, Clinically Proven

Plinest® is supported by clinical studies researching improvements in:

  • Hydration
  • Elasticity
  • Smoothness and texture
  • Fine lines
  • Skin density
  • Under-eye quality
  • Tissue repair and restructuring

In these studies, Plinest® has demonstrated measurable outcomes such as:

  • +21% improved elasticity
  • +14% increased hydration
  • 91% patient-reported improvement

This makes Plinest® one of the most well-documented polynucleotide injectables currently available.

DermaFocus: Bringing Safe Regeneration to UK and Ireland

While Mastelli develops and manufactures Plinest®, DermaFocus ensures that the product is introduced, distributed and used properly within the UK and Irish aesthetic community.

What DermaFocus ensures:

  • Medical-grade distribution only
    Plinest® is supplied exclusively to trained, qualified medical professionals.
  • Consistent practitioner training
    Practitioners receive approved education on techniques, safety, clinical applications and product handling.
  • Authentic product assurance
    Clinics receive genuine Mastelli formulations with full traceability and correct storage conditions.
  • Clinical governance and guidance
    DermaFocus supports practitioners with ongoing education, safety updates and product expertise.

This ensures that Plinest® is delivered exactly as intended – safely, responsibly and in line with the manufacturer’s standards.

Why This Partnership Matters

Why This Partnership Matters

In an industry that is rapidly growing, and where not all products meet the same quality standards, the Mastelli x DermaFocus partnership provides reassurance built on:

  • Scientific credibility
  • Pharmaceutical standards
  • Ethical, controlled distribution
  • High practitioner training
  • Commitment to patient safety

Patients benefit from both Mastelli’s deep scientific heritage and DermaFocus’s responsible, clinician-focused approach to bringing regenerative treatments to the UK and Ireland.

A Shared Mission: Skin Health First

Both Mastelli and DermaFocus are aligned in a simple but powerful mission:
to support healthy, well-functioning skin through safe, science-led regeneration.

Plinest® is a reflection of that mission – a treatment designed to enhance the skin’s natural biology, not override it.

As regenerative aesthetics continues to evolve, Plinest® remains at the forefront thanks to this strong foundation of research, integrity and clinical excellence.

Find your nearest Plinest® clinic here!

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